Under the DOD National Project “Drugs from Sea”, so far about 800 species of marine flora and fauna have been collected and identified from different coastal areas. About 60 new flora and 190 new fauna were collected for general biological screening. Repeat collection of 19 flora and fauna was also made for confirmation of biological activities and follow-up studies. Biological activity was observed in 23 crude extracts and confirmation of activity in follow-up fractions/pure compounds had been located in 7 organisms.

The six marine organisms showing potent anti-diabetic/anti-diarrhoeal; anti- hyperlipidaemic, anti-anxiety, anti-cholesterol cum antioxidant; anti-bacterial cum anti- fungal and larvicidal activities were taken up for product development. Bioassay guided modification of extraction procedure for CDR-134 for separation of active principles responsible for anti-diabetic and anti-diarrhoeal activities was found to be successful. One of the preparations showed consistently anti-diabetic activity in animal models and was devoid of anti-diarrhoeal activity. The other preparation showed anti-diarrhoeal activity. Pre-clinical studies on these two preparations and on anti-hyperlipidaemic fish oil preparations are progressing satisfactorily. Product development work on anti- anxiety, anti-cholesterol cum antioxidant; anti-fungal/anti-bactorial organisms will also be undertaken.